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Cell CANARY
Cell CANARY (Cellular Analysis and Notification of Antigen Risks and Yields) is a recent technology that uses genetically engineered B cells to identify pathogens.〔Petrovick, Martha S., James D. Harper, Frances E. Nargi, Eric D. Schwoebel, Mark C. Hennessy, Todd H. Rider, and Mark A. Hollis. "Rapid Sensors for Biological-Agent Identification." http://www.ll.mit.edu/publications/journal/pdf/vol17_no1/17_1_3Petrovick.pdf. Web. 6 May 2012.〕 Existing pathogen detection technologies include the Integrated Biological Detection System and the Joint Chemical Agent Detector.〔Petrovick, Martha S., James D. Harper, Frances E. Nargi, Eric D. Schwoebel, Mark C. Hennessy, Todd H. Rider, and Mark A. Hollis. "Rapid Sensors for Biological-Agent Identification." http://www.ll.mit.edu/publications/journal/pdf/vol17_no1/17_1_3Petrovick.pdf. Web. 6 May 2012.〕 ==History== In 2007, Benjamin Shapiro, Pamela Abshire, Elisabeth Smela, and Denis Wirtz were granted a patent entitled “Cell Canaries for Biochemical Pathogen Detection. They have successfully manipulated the sensors so that they are sensitive to exposure of certain dangers, such as explosive materials or biological pathogens. What sets CANARY apart from the other methods is that the system is quicker and has a lower number of false readings.〔New Cell-Based Sensors Sniff Out Danger Like Bloodhounds. Science Daily (). 2008 May 6 (2011 December 5 ).〕 Existing pathogen detection methods required that a sample be packaged and sent to a lab where techniques such as mass spectrometry and Polymerase Chain Reaction ultimately provided a blueprint of the nucleotide sequences present in a sample. The pathogen was then determined based on a database of pathogen nucleotides on file. This often resulted in a large amount of false positives and false negatives due to the non-specific nature of nucleotide binding. These techniques also required time that is not feasible in imminent situations.〔P. Belgrader, M. Okuzumi, F. Pourahmadi, D.A. Borkholder, and M.A. Northrup, “A Microfluidic Cartridge to Prepare Spores for PCR Analysis,” Biosens. Bioelectron., vol. 14, nos. 10–11, 2000, pp. 849–852.〕
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